11/4/2022 0 Comments High performance probeAs a result of the extensive PEGylation, Oxyphor 2P exhibits nearly unlimited aqueous solubility and shows no signs of aggregation even at concentrations >100-fold exceeding those required for imaging (typically ∼5 μM). According to molecular mechanics simulations (AMBER force field), in a folded state the probe is ∼7 nm in diameter ( Figure 1C). The dendrimer was constructed from arylglycine-glutamic acid fragments and modified on the periphery with polyethyleneglycol (PEG)-amine residues (Av. The linkers, appended to the 2,6-positions, were thus directed above and below the macrocycle plane facilitating attachment of the bulky dendrons. The phthalimide nitrogens on PtTAPIP were extended by 2,6-substituted aryl groups ( Figure 1D) to prevent intermolecular π-π stacking of otherwise completely planar structures ( Figure S1A). Oxyphor 2P opens up new possibilities for studies of tissue metabolic states using 2PLM in a wide range of biomedical research areas. As proof of principle, we monitored oxygen dynamics for days following micro-stroke induced by occlusion of a single capillary in the mouse brain. Oxyphor 2P allows longitudinal oxygen measurements without having to inject the probe directly into the imaged region. Here, we report a new sensor, Oxyphor 2P, that enables oxygen microscopy twice as deep (up to 600 μm below the tissue surface) and with ∼60 times higher speed than previously possible. Two-photon phosphorescence lifetime microscopy (2PLM) has been developed to perform measurements of oxygen in vivo with micron-scale resolution in 3D however, the method’s potential has not yet been fully realized due to the limitations of current phosphorescent probe technology. spoken high from the customers.Quantitative imaging of oxygen distributions in tissue can provide invaluable information about metabolism in normal and diseased states. #HIGH PERFORMANCE PROBE SERIES#We can offer good guarantee for our customers.Ģ007, TMTeck Manufacturing Limited was founded ,our first kind of product launched successfully– series of coating thickness gaugeĢ008, series of ultrasonic flaw detector come out, enjoying high reputation in European and American countries.Ģ009, series Leeb Hardness Tester come to market successfully, the market reated strongly.Ģ010, our Beijing company TMTeck Instrument Co., Ltd was founded.Ģ011, the flagship product -Ultrasonic Thickness Gauge successfully developed, drive the performance more than one millionĢ014, successfully developed the technology to make all kinds of ultrasonic probes that can meet the needs of GE, OLYMPUS and other western countries’ instruments.Ģ015, The most attractive products - A & B Scan TM281 series Ultrasonic Thickness Gauge come out. And we are developing new series products according to the market demand. With our continued emphasis on customer focus and global competitiveness, TMTeck has always been one of the top tier of world class companies when it comes to leading in NDT equipment. We design and produce a wide range of high performance NDT equipment and accessories. TMTeck is committed to the maintenance of long-term partnership with our clients by offering unparalleled services, technology advice and assistance. These products are widely used in the analysis of materials that enable our customers to monitor, control and validate their critical processes and applications,also our goods has CE certificates. TMTeck Instrument Co., Ltd.(hereafter:TMTeck) is a leading NDT manufacturers and suppliers in Beijing China and provides innovative technologies and comprehensive know-how to benefit customers in a lot of countries around the world.Till now,TMTeck has been active in the areas of technology-driven inspection solutions that deliver productivity, quality and safety.īegan from the Ultrasonic Transducers and Coating Thickness Gauge ,now TMTeck has developed more than 10 series of testing instruments, including Ultrasonic Flaw Detector, Coating Thickness Gauge,Hardness Testers,Ultrasonic Thickness Gauge ,their accessories and other NDT instruments. Complete with handle, lead, plug, neon holder and neon
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